Volume 21, Issue 2 (8-2024)
lmj 2024, 21(2): 20-29 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
nazemizadeh A, sarafrazi F, rasouli H, hashemi nazari S S, hesaraki M. The role of hair follicles stem cells in clinical practice and wound healing. lmj 2024; 21 (2) :20-29
URL: http://icml.ir/article-1-651-en.html
URL: http://icml.ir/article-1-651-en.html
Armin Nazemizadeh 
, Fereshteh Sarafrazi , Hassan Rasouli , Seyed saeid Hashemi nazari , Mahdi Hesaraki *
, Fereshteh Sarafrazi , Hassan Rasouli , Seyed saeid Hashemi nazari , Mahdi Hesaraki *
Abstract: (691 Views)
Except for the palms and soles, the majority of the human skin surface is covered by hair follicles (HF). Hair follicles mostly produce thin and tiny hair stalks that are hardly visible to the naked eye and have a diameter of less than 30 micrometers, which are called unwanted hairs. Other human HFs, which have a lower percentage than the previous type, produce thicker hair shafts with a diameter of 60 µm, known as terminal hairs, and are located in androgen-dependent areas such as the scalp, armpits, and pubic areas. Unlike other mammals, the role of human hair in thermal and shock insulation is insignificant, and the most likely main role of hair follicles in human skin is not the production of hair stems, but participation in functions such as skin homeostasis and wound healing response to surface skin damage. Easy access to hair follicles in humans and their unique feature in the cycle of self-destruction and self-renewal make this microorganism very valuable for stem cell biologists. Hair follicle stem cells (HFSCs) are located in the protruding region of the external root sheath and dermal papilla of the hair follicle and are considered slow cycle cells that have the potential of multilineage differentiation and high proliferation capacity. The normal morphology and periodic growth of HFSCs play an important role in normal skin function, wound healing and skin regeneration. Hair follicle is a powerful enhancer for wound healing, but the application of this new idea in clinical practice is still in its early stages.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
