دوره 22، شماره 1 - ( 4-1404 )
جلد 22 شماره 1 صفحات 29-10 |
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Shams S, Nasiri N, Nazemizadeh A, Haghdoost F, Hashemi S S, Tabaie S M, et al . New advances in responsive smart hydrogel dressings: A perspective for clinical improvement of diabetic wounds. ASWTR 2025; 22 (1) :10-29
URL: http://icml.ir/article-1-678-fa.html
URL: http://icml.ir/article-1-678-fa.html
شمس سروش، نصیری ناهید، ناظمی زاده آرمین، حقدوست فاطمه، هاشمی سیدسعید، طبایی سیدمهدی، و همکاران.. پیشــرفت های نوین در پانســمان های هیدروژل هوشمند پاسخگو: چشم اندازی برای بهبود بالینی زخم های دیابتی. Advances in Skin, Wound and Tissue Repair. 1404; 22 (1) :10-29
سروش شمس 
، ناهید نصیری ، آرمین ناظمی زاده ، فاطمه حقدوست* ، سیدسعید هاشمی ، سیدمهدی طبایی ، مسعود حبیبی ، سیدحسام الدین علامه
، ناهید نصیری ، آرمین ناظمی زاده ، فاطمه حقدوست* ، سیدسعید هاشمی ، سیدمهدی طبایی ، مسعود حبیبی ، سیدحسام الدین علامه
گروه پژوهشــی پزشکی بازســاختی و زیست فناوری در ترمیم زخم، مرکز تحقیقات لیزر در پزشکی، پژوهشکده یارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران
چکیده: (332 مشاهده)
The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings can be an effective strategy for the treatment of diabetic wounds due to their excellent hydrophilicity, good drug loading ability, and sustained drug release properties. However, the drug release and degradation behavior of hydrogel wound dressings used in the clinic cannot be tuned according to the wound microenvironment. Due to the complexity of diabetic wounds, antibiotics and other drugs are often combined with hydrogel dressings in clinical use. Researchers have developed responsive hydrogel dressings based on the characteristics of the diabetic wound microenvironment, such as high glucose and low pH, or in combination with external stimuli (such as light or magnetic field), to achieve controlled drug release, gel degradation, and microenvironment improvement, and overcome clinical problems. It is predicted that in the future, reactive hydrogel dressings will play an important role in diabetic wound healing dressings. In this review, recent advances in reactive hydrogel dressings for diabetic wound healing are reviewed, focusing on the hydrogel structure design, reactivity principle, and degradation behavior. Finally, the advantages and limitations of these reactive hydrogels in clinical applications are also discussed. It is hoped that this review will contribute to further progress in the field of hydrogels as improved dressings for diabetic wound healing and clinical application.
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