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ASWTR 2025, 22(2): 1-9 |
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Rashnoodi A. An Overview of the Principles and Basics of Photodynamic Therapy. ASWTR 2025; 22 (2) :1-9
URL: http://icml.ir/article-1-672-en.html
URL: http://icml.ir/article-1-672-en.html
Department of Biomedical Engineering and Medical Physics, Faculty of Medicine, Shahid Beheshti University of medical Sciences, Tehran, Iran
Abstract: (26 Views)
Introduction: Photodynamic therapy (PDT) is an innovative and non-invasive treatment modality that utilizes photosensitizing agents, light of specific wavelengths, and molecular oxygen to generate reactive oxygen species, leading to the selective destruction of target cells.
Methods: This article reviews the fundamental principles of PDT, the various generations of photosensitizers, and its broad applications in the treatment of cancers, drug-resistant infections, ocular diseases, and biofilm eradication.
Results: The advantages of PDT include minimal invasiveness, low systemic toxicity, and short treatment duration. However, challenges such as limited light penetration, oxygen dependency, and insufficient photosensitizer accumulation persist.
Conclusions: Strategies involving the use of nanoparticles to enhance targeting and efficacy, as well as approaches such as combination therapies and dosimetry optimization, have been proposed to address these limitations. Overall, the development of next-generation photosensitizers and intelligent drug delivery systems heralds a promising future for the treatment of cancers and resistant infections.
Methods: This article reviews the fundamental principles of PDT, the various generations of photosensitizers, and its broad applications in the treatment of cancers, drug-resistant infections, ocular diseases, and biofilm eradication.
Results: The advantages of PDT include minimal invasiveness, low systemic toxicity, and short treatment duration. However, challenges such as limited light penetration, oxygen dependency, and insufficient photosensitizer accumulation persist.
Conclusions: Strategies involving the use of nanoparticles to enhance targeting and efficacy, as well as approaches such as combination therapies and dosimetry optimization, have been proposed to address these limitations. Overall, the development of next-generation photosensitizers and intelligent drug delivery systems heralds a promising future for the treatment of cancers and resistant infections.
Educational: Review |
Subject:
General
Received: 2025/07/25 | Accepted: 2025/09/24 | Published: 2025/12/14
Received: 2025/07/25 | Accepted: 2025/09/24 | Published: 2025/12/14
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