Volume 19, Issue 2 (Journaloflasersinmedicine 2022)
lmj 2022, 19(2): 63-71 |
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Matroodi F. Raman Spectroscopy and its Applications in Medicine and Detection of Viruses. lmj 2022; 19 (2) :63-71
URL: http://icml.ir/article-1-569-en.html
URL: http://icml.ir/article-1-569-en.html
Golestan Blvd., Ahvaz, Iran
Abstract: (860 Views)
Introduction: In Raman spectroscopy, usually, a laser is used to excite the sample then the scattered light from the sample is collected which is containing the vibrational levels information and serves as a fingerprint of the sample. In Raman technique, light is not absorbed by the sample, therefore, Raman spectroscopy has a minimum effect on the sample and it is extensively useful in live tissue and cell applications. In this study, Raman spectroscopy is introduced and varieties of this technique are compared regarding medical applications. Also, some studies using Raman spectroscopy for virus detection including alike COVID 19 are listed.
Methodology: Papers that used for this study are selected from Raman Spectroscopy journal and as well google scholar and ACS web sites.
Results: The sensitivity of spontaneous Raman spectroscopy is very low, as a result enhanced techniques including stimulated Raman, CARS, SERS and resonance Raman show more applications in medical studies. SERS needs a use of nanostructure to enhance Raman effect. That leads to be mostly applicable in lab and cell studies. Stimulated Raman and CARS are able to do in-vivo and in-situ imaging of the living creatures. Differentiation of similar species is possible by combining Raman with multivariate methods.
Conclusion: By Raman spectroscopy, high resolution images and movies of the interaction of the drug with a live tissue can be achieved. Combining Raman with statistical methods, recently, shows extensive applications in virus detection.
Methodology: Papers that used for this study are selected from Raman Spectroscopy journal and as well google scholar and ACS web sites.
Results: The sensitivity of spontaneous Raman spectroscopy is very low, as a result enhanced techniques including stimulated Raman, CARS, SERS and resonance Raman show more applications in medical studies. SERS needs a use of nanostructure to enhance Raman effect. That leads to be mostly applicable in lab and cell studies. Stimulated Raman and CARS are able to do in-vivo and in-situ imaging of the living creatures. Differentiation of similar species is possible by combining Raman with multivariate methods.
Conclusion: By Raman spectroscopy, high resolution images and movies of the interaction of the drug with a live tissue can be achieved. Combining Raman with statistical methods, recently, shows extensive applications in virus detection.
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Received: 2022/11/16 | Accepted: 2022/11/1 | Published: 2022/11/1
Received: 2022/11/16 | Accepted: 2022/11/1 | Published: 2022/11/1
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