fa افزایش کارایی فوتودینامیک تراپی تومورهای مغزی با استفاده از نانوتکنولوژی عمومى General مروری Review <div style="text-align: justify;"><strong>Introduction:</strong> This review aims to introduce and evaluate photodynamic therapy as a targeted, localized treatment modality. Its primary goal is to demonstrate photodynamic therapy&#39;s potential as a precise photochemical surgical tool for eradicating brain tumor cells in regions inaccessible to conventional therapies, while minimizing adverse effects.<br> <strong>Methods:</strong> A comprehensive literature review was conducted, examining the principles of photodynamic therapy, its applications in brain tumor therapy, and various photosensitizers. Data were synthesized from credible scientific sources, including clinical, pre-clinical, and in vitro studies. The mechanism of photodynamic therapy is explained, focusing on the three key elements: the photosensitizer, light source, and molecular oxygen. The properties and applications of seven principal PS agents&mdash;Porfimer Sodium, 5-Aminolevulinic Acid, Temoporfin, Chlorin, Talaporfin, Hypericin, and Phthalocyanines&mdash;are analyzed. The role of novel nanotechnological strategies in enhancing therapeutic efficacy is also explored.<br> <strong>Results:</strong> Evidence from the literature confirms that photodynamic therapy, utilizing various photosensitizers, is effective in destroying glioblastoma cells. Studies employing different photosensitizers doses (e.g., 1&ndash;2.5 &micro;g/mL for Porfimer Sodium) and light doses (ranging from 4 to 100 J/cm&sup2;) have achieved significant therapeutic outcomes. Photodynamic therapy has been shown to inhibit glioma cell dynamism and migration, induce apoptosis, and reduce tumor volume. Several clinical studies report a markedly increased survival rate compared to standard treatments. While photodynamic therapy demonstrates better systemic tolerability than conventional therapies, local side effects, including cerebral edema and skin photosensitivity, are noted. Nanotechnology-based approaches improve treatment efficacy by enhancing blood-brain barrier penetration and promoting the selective accumulation of photosensitizers within the tumor.<br> <strong>Conclusions:</strong> Photodynamic therapy represents a promising, minimally invasive adjuvant therapy for brain tumors, especially inoperable ones. Despite challenges like limited light penetration, poor solubility of some photosensitizers agents, and tumor heterogeneity, advancements in third-generation photosensitizers, nanoparticle-based delivery systems, and combination therapies are poised to improve outcomes and reduce toxicity. Future research should focus on optimizing treatment protocols, enhancing photosensitizers bioavailability, and conducting large-scale clinical evaluations of side effects.</div> Brain tumor, Theranostic, Photosensitizer, Cancer Treatment, Photodynamic Therapy, Glioblastoma, Nanotechnology. 1 17 http://icml.ir/browse.php?a_code=A-10-656-1&slc_lang=fa&sid=1 Yasaman Golian یاسمن گلیان y.golian@gmail.com 1050031947532846005570 1050031947532846005570 Yes Department of Physics, Central Tehran Branch, Islamic Azad University, Tehran, Iran گروه فیزیک، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران Saleheh Beheshtipour صالحه بهشتی پور Saleheh1383@yahoo.com 1050031947532846005571 1050031947532846005571 No Institute of Biosocial and Quantum Science and Technologies, CT.C, Islamic Azad University, Tehran, Iran دانشکده علوم و فناوری‌های زیست اجتماعی و کوانتومی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران