fa درمان سرطان پوست با روش فوتوترمال با استفاده از شبیه‌سازی کامسول با کمک تزریق نانوذرات عمومى General كاربردي Applicable <div style="text-align: justify;"><strong>Introduction</strong>: In this study, the photothermal therapy method for treating cancerous skin tissue using laser irradiation is investigated. In this therapeutic approach, gold nanoparticles are cumulatively injected into the tumor tissue. Photothermal therapy incorporating gold nanoparticles is simulated using COMSOL Multiphysics. The effects of pulsed and continuous laser irradiation are evaluated both in the presence and absence of nanoparticles. To minimize the reduction of photon flux during the transmission of visible light through tissue to the tumor, and to enhance penetration depth, a near-infrared diode laser wavelength is employed.<br> <strong>Methods</strong>: In this research, simulations were performed under two conditions: with and without gold nanoparticles. The outcomes were analyzed using two types of laser irradiation&mdash;pulsed and continuous&mdash;employed as heat sources in photothermal therapy. Among the obtained results, the most effective therapeutic approach was identified as the one that caused the least damage to the surrounding healthy tissue while inducing the greatest destruction in the malignant tissue.<br> <strong>Results</strong>: The simulations indicated that adding gold nanoparticles noticeably improved the effectiveness of photothermal therapy by directing heat toward the tumor. Without the nanoparticles, both pulsed and continuous lasers produced only minor necrosis of cancer cells. When nanoparticles were present, pulsed laser irradiation led to a more controlled rise in tumor temperature, causing less harm to the nearby healthy tissue. In contrast, continuous laser exposure resulted in considerable damage to the surrounding healthy region.<br> <strong>Conclusions</strong>: Based on the simulations, the best approach for photothermal treatment of skin cancer appears to be using gold nanoparticles together with pulsed laser irradiation. This combination effectively destroyed the tumor while keeping damage to the surrounding healthy tissue to a minimum. While continuous laser could also kill tumor cells, it caused much more harm to the nearby healthy tissue.</div> Skin Cancer, COMSOL, Nanoparticles, Photothermal 18 28 http://icml.ir/browse.php?a_code=A-10-361-5&slc_lang=fa&sid=1 fatemeh Rezaei فاطمه رضائی fatemehrezaei@kntu.ac.ir 1050031947532846005572 1050031947532846005572 Yes Faculty Member, Biophotonic Laboratory, Physics Faculty, K. N. Toosi University of Technology, Tehran, Iran هیئت علمی دانشگاه، آزمایشگاه بیوفتونیک، دانشکده فیزیک، دانشگاه خواجه نصیر الدین طوسی، تهران، ایران Narges Savaedi نرگس سواعدی narges.savaedi@gmail.com 1050031947532846005573 1050031947532846005573 No Biophotonic Laboratory, Physics Faculty, K. N. Toosi University of Technology, Tehran, Iran آزمایشگاه بیوفتونیک، دانشکده فیزیک، دانشگاه خواجه نصیر الدین طوسی، تهران، ایران Saeedeh Kabiri سعیده کبیری kabiri.1369@gmail.com 1050031947532846005574 1050031947532846005574 No School of Electronic and Electrical Engineering, University of Leeds of England, UK دانشکده الکترونیک و مهندسی الکتریک، دانشگاه لید، انگلستان Hossein Akhavan حسین اخوان akhavanhossein.2000@yahoo.com 1050031947532846005575 1050031947532846005575 No K. N. Toosi University of Technology دانشگاه خواجه نصیر الدین طوسی