<?xml version="1.0" encoding="utf-8"?>
<journal>
<title>Advances in Skin, Wound and Tissue Repair</title>
<title_fa>Advances in Skin, Wound and Tissue Repair</title_fa>
<short_title>ASWTR</short_title>
<subject>Medical Sciences</subject>
<web_url>http://icml.ir</web_url>
<journal_hbi_system_id>105</journal_hbi_system_id>
<journal_hbi_system_user>journal105</journal_hbi_system_user>
<journal_id_issn></journal_id_issn>
<journal_id_issn_online>3116-1677</journal_id_issn_online>
<journal_id_pii></journal_id_pii>
<journal_id_doi>10.61882/aswtr</journal_id_doi>
<journal_id_iranmedex></journal_id_iranmedex>
<journal_id_magiran></journal_id_magiran>
<journal_id_sid></journal_id_sid>
<journal_id_nlai></journal_id_nlai>
<journal_id_science></journal_id_science>
<language>en</language>
<pubdate>
	<type>jalali</type>
	<year>1403</year>
	<month>10</month>
	<day>1</day>
</pubdate>
<pubdate>
	<type>gregorian</type>
	<year>2025</year>
	<month>1</month>
	<day>1</day>
</pubdate>
<volume>22</volume>
<number>1</number>
<publish_type>online</publish_type>
<publish_edition>1</publish_edition>
<article_type>fulltext</article_type>
<articleset>
	<article>


	<language>fa</language>
	<article_id_doi></article_id_doi>
	<title_fa>پیشــرفت های نوین در پانســمان های هیدروژل هوشمند پاسخگو: چشم اندازی برای بهبود بالینی زخم های دیابتی</title_fa>
	<title>New advances in responsive smart hydrogel dressings: A perspective for clinical improvement of diabetic wounds</title>
	<subject_fa>عمومى</subject_fa>
	<subject>General</subject>
	<content_type_fa>مروری</content_type_fa>
	<content_type>Review</content_type>
	<abstract_fa></abstract_fa>
	<abstract>&lt;span style=&quot;font-size:11pt&quot;&gt;&lt;span style=&quot;tab-stops:147.75pt&quot;&gt;&lt;span style=&quot;line-height:107%&quot;&gt;&lt;span style=&quot;font-family:Calibri,sans-serif&quot;&gt;&lt;span style=&quot;font-size:12.0pt&quot;&gt;&lt;span style=&quot;line-height:107%&quot;&gt;&lt;span new=&quot;&quot; roman=&quot;&quot; style=&quot;font-family:&quot; times=&quot;&quot;&gt;&amp;nbsp;The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings can be an effective strategy for the treatment of diabetic wounds due to their excellent hydrophilicity, good drug loading ability, and sustained drug release properties. However, the drug release and degradation behavior of hydrogel wound dressings used in the clinic cannot be tuned according to the wound microenvironment. Due to the complexity of diabetic wounds, antibiotics and other drugs are often combined with hydrogel dressings in clinical use. Researchers have developed responsive hydrogel dressings based on the characteristics of the diabetic wound microenvironment, such as high glucose and low pH, or in combination with external stimuli (such as light or magnetic field), to achieve controlled drug release, gel degradation, and microenvironment improvement, and overcome clinical problems. It is predicted that in the future, reactive hydrogel dressings will play an important role in diabetic wound healing dressings. In this review, recent advances in reactive hydrogel dressings for diabetic wound healing are reviewed, focusing on the hydrogel structure design, reactivity principle, and degradation behavior. Finally, the advantages and limitations of these reactive hydrogels in clinical applications are also discussed. It is hoped that this review will contribute to further progress in the field of hydrogels as improved dressings for diabetic wound healing and clinical application.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;br&gt;
&amp;nbsp;</abstract>
	<keyword_fa></keyword_fa>
	<keyword>Smart hydrogel, controlled drug delivery, nanotechnology in drug delivery, bioactive systems, stimuli-responsive polymers</keyword>
	<start_page>10</start_page>
	<end_page>29</end_page>
	<web_url>http://icml.ir/browse.php?a_code=A-10-585-1&amp;slc_lang=fa&amp;sid=1</web_url>


<author_list>
	<author>
	<first_name>Soroush</first_name>
	<middle_name></middle_name>
	<last_name>Shams</last_name>
	<suffix></suffix>
	<first_name_fa>سروش</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>شمس</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005462</code>
	<orcid>1050031947532846005462</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>1Departmnt of Regenerative Medicine and Biotechnology in Wound Healing, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه پژوهشــی پزشکی بازســاختی و زیست فناوری در ترمیم زخم، مرکز تحقیقات لیزر در پزشکی، پژوهشکده یارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Nahid</first_name>
	<middle_name></middle_name>
	<last_name>Nasiri</last_name>
	<suffix></suffix>
	<first_name_fa>ناهید</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>نصیری</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005463</code>
	<orcid>1050031947532846005463</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>2 Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه پژوهشی لیزر پزشــکی، مرکز تحقیقات لیــزر در پزشــکی، پژوهشــکده یــارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Armin </first_name>
	<middle_name></middle_name>
	<last_name>Nazemizadeh</last_name>
	<suffix></suffix>
	<first_name_fa>آرمین</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>ناظمی زاده</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005464</code>
	<orcid>1050031947532846005464</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>1Departmnt of Regenerative Medicine and Biotechnology in Wound Healing, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه پژوهشــی پزشکی بازســاختی و زیست فناوری در ترمیم زخم، مرکز تحقیقات لیزر در پزشکی، پژوهشکده یارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Fatemeh </first_name>
	<middle_name></middle_name>
	<last_name>Haghdoost</last_name>
	<suffix></suffix>
	<first_name_fa>فاطمه</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>حقدوست</last_name_fa>
	<suffix_fa></suffix_fa>
	<email>haghdoost@gmail.com</email>
	<code>1050031947532846005465</code>
	<orcid>1050031947532846005465</orcid>
	<coreauthor>Yes
</coreauthor>
	<affiliation>1Departmnt of Regenerative Medicine and Biotechnology in Wound Healing, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه پژوهشــی پزشکی بازســاختی و زیست فناوری در ترمیم زخم، مرکز تحقیقات لیزر در پزشکی، پژوهشکده یارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Seyed Saeid </first_name>
	<middle_name></middle_name>
	<last_name>Hashemi</last_name>
	<suffix></suffix>
	<first_name_fa>سیدسعید</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>هاشمی</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005466</code>
	<orcid>1050031947532846005466</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>3Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran</affiliation>
	<affiliation_fa>گروه اپیدمیولوژی، دانشکده بهداشت و ایمنی، دانشــگاه علوم پزشــکی و خدمات بهداشــتی درمانی شهید بهشتی، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Seyed Mehdi</first_name>
	<middle_name></middle_name>
	<last_name>Tabaie</last_name>
	<suffix></suffix>
	<first_name_fa>سیدمهدی</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>طبایی</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005467</code>
	<orcid>1050031947532846005467</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>2 Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه پژوهشی لیزر پزشــکی، مرکز تحقیقات لیــزر در پزشــکی، پژوهشــکده یــارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Masoud</first_name>
	<middle_name></middle_name>
	<last_name>Habibi</last_name>
	<suffix></suffix>
	<first_name_fa>مسعود</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>حبیبی</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005468</code>
	<orcid>1050031947532846005468</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>1Departmnt of Regenerative Medicine and Biotechnology in Wound Healing, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه پژوهشــی پزشکی بازســاختی و زیست فناوری در ترمیم زخم، مرکز تحقیقات لیزر در پزشکی، پژوهشکده یارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


	<author>
	<first_name>Seyed Hesamoddin</first_name>
	<middle_name></middle_name>
	<last_name>Alameh</last_name>
	<suffix></suffix>
	<first_name_fa>سیدحسام الدین</first_name_fa>
	<middle_name_fa></middle_name_fa>
	<last_name_fa>علامه</last_name_fa>
	<suffix_fa></suffix_fa>
	<email></email>
	<code>1050031947532846005469</code>
	<orcid>1050031947532846005469</orcid>
	<coreauthor>No</coreauthor>
	<affiliation>Department of Life Style Medicine, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran</affiliation>
	<affiliation_fa>گروه سبک زندگی، پژوهشکده زخم و ترمیم بافت یارا، جهاد دانشگاهی علوم پزشکی تهران، تهران، ایران</affiliation_fa>
	 </author>


</author_list>


	</article>
</articleset>
</journal>
