Advances in Skin, Wound and Tissue Repair
Advances in Skin, Wound and Tissue Repair
ASWTR
Medical Sciences
http://icml.ir
105
journal105
1735-3319
10.61882/aswtr
en
jalali
1403
4
1
gregorian
2024
7
1
21
1
online
1
fulltext
fa
اثر درمان فتودینامیکی داروی حساس به نور ALA-۵
بر توان زیستی سلولهای سرطانی گلیوبلاستوما (۶C)
The effect of photodynamic treatment of photosensitizing drug
ALA-5 on the viability of glioblastoma cancer cells (6C)
عمومى
General
پژوهشي
Research
<div style="text-align: justify;"><span style="line-height:2;"><span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span class="StyleLatinHelveticaComplex2LotusLatin12ptComple" new="" roman="" times=""><span style="color:black"><b><span lang="AR-SA"><span style="color:red">اهداف:</span></span></b></span></span> <span lang="AR-SA">گلیوبلاستوما، یکی از انواع تومورهای مغزی با بالاترین درجه بدخیمی و عود بالا است. روشهای کنونی درمان شامل ِ جراحی، پرتو درمانی و شیمی</span><span dir="LTR">‎</span><span lang="AR-SA">درمانی است که هر یک عوارض بسیاری را به</span><span dir="LTR">‎</span><span lang="AR-SA">دنبال دارند. فوتودینامیک درمانی (</span><span dir="LTR">PDT</span><span lang="AR-SA">)، روش جدید القای مرگ سلولی مبتنی بر واکنش متقابل سه عامل داروی حساس به نور، منبع نور و اکسیژن است که انتخابی و کم تهاجمی بوده و عوارض جانبی کمتری نسبت به روشهای متداول دارد. در این روش، ترکیب داروی حساس به نور و پرتو لیزر از</span><span dir="LTR">‎</span><span lang="AR-SA">طریق برهمکنشهای فوتوشیمیایی سبب تولید اکسیژن سمی (سیتوتوکسیک) فعال و رادیکالهای آزاد</span><span dir="LTR">‎</span><span lang="AR-SA">شده که به</span><span dir="LTR">‎</span><span lang="AR-SA">طور انتخابی، مرگ سلولی را به همراه دارد.</span> <span lang="AR-SA">هدف از این پژوهش، بررسی تأثیر </span><span dir="LTR">PDT</span><span lang="AR-SA"> در زندهمانی رده سلولی گلیوبلاستوما (۶</span><span dir="LTR">C</span><span lang="AR-SA">) با استفاده از ماده حساس به نور </span><span dir="LTR">ALA</span><span lang="AR-SA">-۵ در غلظتهای مختلف است.</span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span class="StyleLatinHelveticaComplex2LotusLatin12ptComple" new="" roman="" times=""><span style="color:black"><b><span lang="AR-SA"><span style="color:red">روش بررسی:</span></span></b></span></span> <span lang="AR-SA">ابتدا سلولهای رده ۶</span><span dir="LTR">C</span><span lang="AR-SA"> در محیط کشت </span><span dir="LTR">DMEM</span> کشت داده شده است. سپس، تیمار سلولهای سرطانی توسط لیزر دیود پیوسته کم توان در طولموج <span dir="LTR">nm</span><span lang="AR-SA"> ۶۳۵ با توان </span><span dir="LTR">mW</span><span lang="AR-SA"> ۲۰، در دزهای نوری ۲</span><span dir="LTR">J/cm</span><span lang="AR-SA"> ۴/۵۶ و ۲</span><span dir="LTR">J/cm</span><span lang="AR-SA"> ۸/۱۱۲ و غلظتهای مختلف دارو (25، 50، ۷۵، 100 و </span><span dir="LTR">μg/ml</span><span lang="AR-SA"> ۱۲۵) با روش تست </span><span dir="LTR">MTT</span><span lang="AR-SA"> بررسی شده است.</span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span class="StyleLatinHelveticaComplex2LotusLatin12ptComple" new="" roman="" times=""><span style="color:black"><b><span lang="AR-SA"><span style="color:red">یافتهها:</span></span></b></span></span> <span lang="AR-SA">نتایج نشان میدهند که در روش </span><span dir="LTR">PDT</span><span lang="AR-SA"> سلولهای ۶</span><span dir="LTR">C</span><span lang="AR-SA"> با ماده حساس به نور </span><span dir="LTR">ALA</span><span lang="AR-SA">-۵، کاهش چشمگیری در تعداد سلولهای گروه درمان فوتودینامیکی در مقایسه با گروه </span><span dir="LTR">ALA</span><span lang="AR-SA">-۵ بدون لیزر و لیزر بدون </span><span dir="LTR">ALA</span><span lang="AR-SA">-۵ دیده میشود. اعمال داروی </span><span dir="LTR">ALA</span><span lang="AR-SA">-۵ سبب افزایش تولید ماده حساس به نور اصلی </span><span dir="LTR">PPIX</span><span lang="AR-SA"> و در</span><span dir="LTR">‎</span><span lang="AR-SA">نتیجه افزایش مرگ سلولی میشود.</span></span></span><br>
<span class="StyleLatinHelveticaComplex2LotusLatin12ptComple" new="" roman="" times=""><span style="color:black"><b><span dir="RTL" lang="AR-SA"><span style="color:red">نتیجهگیری:</span></span></b></span></span> <span dir="RTL" lang="AR-SA">تیمار</span> <span dir="RTL" lang="AR-SA">فوتودینامیکی</span> <span dir="RTL" lang="AR-SA">سلولهای</span> <span dir="RTL" lang="AR-SA">سرطانی</span> <span dir="RTL" lang="AR-SA">۶</span>C <span dir="RTL" lang="AR-SA">با</span> <span dir="RTL" lang="AR-SA">داروی</span> ALA-۵ <span dir="RTL" lang="AR-SA">در</span> <span dir="RTL" lang="AR-SA">غلظت</span> μg/ml <span dir="RTL" lang="AR-SA">۷۵</span> <span dir="RTL" lang="AR-SA">و</span> <span dir="RTL" lang="AR-SA">زمان</span> <span dir="RTL" lang="AR-SA">انکوباسیون</span> h <span dir="RTL" lang="AR-SA">۴</span> <span dir="RTL" lang="AR-SA">به</span> <span dir="RTL" lang="AR-SA">همراه</span> <span dir="RTL" lang="AR-SA">تابش</span> <span dir="RTL" lang="AR-SA">لیزر</span> <span dir="RTL" lang="AR-SA">دایود</span> <span dir="RTL" lang="AR-SA">در</span> <span dir="RTL" lang="AR-SA">طولموج</span> nm <span dir="RTL" lang="AR-SA">۶۳۵</span> <span dir="RTL" lang="AR-SA">با</span> <span dir="RTL" lang="AR-SA">دز</span> <span dir="RTL" lang="AR-SA">نوری</span> <span dir="RTL" lang="AR-SA">۲</span>J/cm <span dir="RTL" lang="AR-SA">۸/۱۱۲</span> <span dir="RTL" lang="AR-SA">بهینه</span> <span dir="RTL" lang="AR-SA">است</span> <span dir="RTL" lang="AR-SA">و</span> <span dir="RTL" lang="AR-SA">بیشترین</span> <span dir="RTL" lang="AR-SA">اثربخشی</span> <span dir="RTL" lang="AR-SA">را</span> <span dir="RTL" lang="AR-SA">در</span> <span dir="RTL" lang="AR-SA">مرگ</span> <span dir="RTL" lang="AR-SA">سلولهای</span> <span dir="RTL" lang="AR-SA">سرطانی</span> <span dir="RTL" lang="AR-SA">به</span> <span dir="RTL" lang="AR-SA">همراه</span> <span dir="RTL" lang="AR-SA">دارد.</span> <span dir="RTL" lang="AR-SA">در</span> <span dir="RTL" lang="AR-SA">این</span> <span dir="RTL" lang="AR-SA">حالت،</span> <span dir="RTL" lang="AR-SA">توان</span> <span dir="RTL" lang="AR-SA">زیستی</span> <span dir="RTL" lang="AR-SA">سلولها</span> <span dir="RTL" lang="AR-SA">تا</span> <span dir="RTL" lang="AR-SA">۳۷%</span> <span dir="RTL" lang="AR-SA">کاهش</span> <span dir="RTL" lang="AR-SA">مییابد.</span> <span dir="RTL" lang="AR-SA">نتایج</span> <span dir="RTL" lang="AR-SA">حاصل،</span> <span dir="RTL" lang="AR-SA">بیانگر</span> <span dir="RTL" lang="AR-SA">حساسیت</span> <span dir="RTL" lang="AR-SA">سلولهای</span> <span dir="RTL" lang="AR-SA">سرطانی</span> <span dir="RTL" lang="AR-SA">بدخیم</span> <span dir="RTL" lang="AR-SA">گلیوبلاستوما</span> <span dir="RTL" lang="AR-SA">به</span> <span dir="RTL" lang="AR-SA">این</span> <span dir="RTL" lang="AR-SA">روش</span> <span dir="RTL" lang="AR-SA">درمانی</span> <span dir="RTL" lang="AR-SA">است.</span></span></span></span></div>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:red">Goals:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#252525"> Glioblastoma is one of the types of brain tumors with the highest degree of malignancy and high recurrence. Current treatment methods include surgery, radiation therapy, and chemotherapy, each of which has many side effects. Photodynamic therapy (PDT), a new method of inducing cell death based on the interaction of three photosensitive drug agents, light source and oxygen, is selective and minimally invasive and has fewer side effects than conventional methods. In this method, the combination of light-sensitive drug and laser beam through photochemical interactions causes the production of active toxic oxygen (cytotoxic) and free radicals that selectively cause cell death. The aim of this research is to investigate the effect of PDT on the survival of glioblastoma cell line (6C) using the photosensitizer ALA-5 in different concentrations.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:red">analysis method:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#252525"> First, 6C cells were cultured in DMEM medium. Then, the treatment of cancer cells by a low-power continuous diode laser at a wavelength of 635 nm with a power of 20 mW, at optical doses of 56.4 J/cm and 112.8 J/cm and different drug concentrations (25, 50, 75, 100 and μg 125/ml) has been checked by MTT test method.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:red">findings:</span></span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#252525"> The results show that in the PDT method of 6C cells with ALA-5 photosensitizer, there is a significant decrease in the number of cells in the photodynamic therapy group compared to the ALA-5 group without laser and the laser without ALA-5. The application of ALA-5 drug increases the production of the main light-sensitive substance PPIX and as a result increases cell death.</span></span></span></span></span></span><br>
<b><i><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:red">Conclusion:</span></span></span></span></i></b> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">Photodynamic</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">treatment</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">6C</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cancer</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cells</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">with</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">ALA-5</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">drug</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">at</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">a</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">concentration</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">75</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">μg/ml</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">and</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">an</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">incubation</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">time</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">4</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">h</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">along</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">with</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">diode</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">laser</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">radiation</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">at</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">a</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">wavelength</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">635</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">nm</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">with</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">a</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">light</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">dose</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">112.8</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">2J/cm</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">is</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">optimal</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">and</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">the</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">most</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">effective</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">in</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">the</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">death</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cancer</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cells.</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">It</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">comes</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">with</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">in</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">this</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">case,</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">the</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">biological</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">power</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">the</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cells</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">decreases</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">by</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">37%.</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">The</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">results</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">show</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">the</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">sensitivity</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">of</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">malignant</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">glioblastoma</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cancer</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">cells</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">to</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">this</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">treatment</span></span></span></span> <span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:#252525">method</span></span></span></span>
فتودینامیک درمانی؛ داروی حساس به نور؛ اکسیژن فعال؛ گلیوبلاستوما
photodynamic therapy, photosensitive drug, active oxygen, glioblastoma
15
22
http://icml.ir/browse.php?a_code=A-10-626-1&slc_lang=fa&sid=1
maryam
ilchi
مریم
ایلچی قزاانی
maryam.ilchi2010@gmail.com
1050031947532846005105
1050031947532846005105
Yes
پژوهشکده فوتونیک و فناوریهای کوانتومی، پژوهشگاه علوم و فنون هستهای، تهران
shima
nezameslami
شیما
نظام الاسلامی
1050031947532846005106
1050031947532846005106
No
گروه فیزیک اتمی مولکولی، دانشکده فیزیک، دانشگاه الزهرا، تهران
batoul
sajjad
بتول
سجاد
1050031947532846005107
1050031947532846005107
No
گروه فیزیک اتمی مولکولی، دانشکده فیزیک، دانشگاه الزهرا، تهران
mohsen
montazerghaem
محسن
منتظرالقائم
1050031947532846005108
1050031947532846005108
No
پژوهشکده فوتونیک و فناوریهای کوانتومی، پژوهشگاه علوم و فنون هستهای، تهران