Advances in Skin, Wound and Tissue Repair
Advances in Skin, Wound and Tissue Repair
ASWTR
Medical Sciences
http://icml.ir
105
journal105
3116-1677
10.61882/aswtr
en
jalali
1400
9
1
gregorian
2021
12
1
18
4
online
1
fulltext
fa
مروری بر حسگر زیستی رامان بهبودیافته سطحی (SERS)
به منظور مطالعه آنالیتهای بیولوژیکی و مواد شیمیایی
A Review of Surface-Enhanced Raman Biosensors for Studying
Different Biological Analytes and Chemicals
عمومى
General
مروری
Review
<div style="text-align: justify;"><span style="font-family:Tahoma;"><span style="font-size:14px;"><span style="line-height:2;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="AR-SA"><span style="color:#0d0d0d">پراکندگی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">رامان</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">بهبودیافته</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">سطحی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">(</span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d">)</span></span> <span lang="AR-SA">یکی</span> <span lang="AR-SA"><span style="color:#0d0d0d">از</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">ابزارهای</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">تحلیلی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">بسیار</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">حساسِ</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">شناختهشده</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">در</span></span><span lang="AR-SA"><span style="color:#0d0d0d"></span></span><span lang="AR-SA"><span style="color:#0d0d0d">حال</span></span><span lang="AR-SA"><span style="color:#0d0d0d"></span></span><span lang="AR-SA"><span style="color:#0d0d0d">حاضر</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">است؛</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">در</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">برخی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">موارد،</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">میتوان</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">طیف</span></span> <span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">با</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">کیفیت</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">بالا</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">که</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">حتی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">یک</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">تک</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">مولکول</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">در</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">آن</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">سهیم</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">است</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">را</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">ثبت</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">کرد.</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">بنابراین،</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">طیفسنجی</span></span> <span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">به</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">عنوان</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">یک</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">گزینه</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">بسیار</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">امیدوارکننده</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">به</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">عنوان</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">جایگزین</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">برای</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">تکنیکهای</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">تحلیلی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">روتین</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">استفادهشده</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">در</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">آنالیزهای</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">مربوط</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">به</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">مواد</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">غذایی،</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">محیط</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">زیست،</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">بیوشیمی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">و</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">پزشکی</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">در</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">نظر</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">گرفته</span></span> <span lang="AR-SA"><span style="color:#0d0d0d">میشود.</span></span> <span lang="AR-SA"><span style="color:#0d0d0d"></span></span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="AR-SA"><span style="color:#0d0d0d">در این مقاله مروری، بهطور خلاصه به کاربردهای قطعی و اخیرِ توسعه دادهشده طیفسنجی </span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d"> برای مشخصهیابی بیوشیمیایی (بهویژه پزشکی و زیستی) ترکیبهای مهم پرداخته شده است. همچنین مبانی نظری اثر </span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d"> را توضیح داده و در مورد کاربردهای آتی </span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d"> در این زمینه بحث گردید. ما امیدواریم که این مقاله برای محققانی که قصد ورود به این زمینه تحقیقاتی شگفتانگیز دارند، موثر واقع گردد.</span></span><b><span lang="AR-SA"><span style="color:#0d0d0d"></span></span></b></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="AR-SA"><span style="color:#0d0d0d">در این مقاله مروری، بهطور خلاصه به کاربردهای قطعیِ توسعه دادهشده </span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d"> برای </span></span><span lang="AR-SA">تشخیص</span><span lang="AR-SA"><span style="color:#0d0d0d"> گونههای مهم از لحاظ بیوشیمیایی (بهویژه پزشکی و زیستی) از سادهترین انواع آنها تا پیچیدهترین آنها پرداخته شده است. همچنین، قابلیت بالقوه </span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d"> برای استفاده به عنوان جایگزینِ روشهای روتین در موارد تشخیصی و بالینی نشان داده میشود. علاوهبراین، در این مقاله توضیح داده شده است که سنسورهای مبتنی بر </span></span><span dir="LTR" lang="EN-GB"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d"> چطور کار میکنند و در آخر به چشماندازهای آتی این زمینه پرداخته میشود.</span></span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="AR-SA"><span style="color:#0d0d0d">در پایان این مطالعه توان با نحوه عملکرد تشخیص، روشهای ساخت مستقیم و غیرمستقیم جهت شناسایی آنالیتهای بیولوژیکی و مواد شیمیایی، کاربرد بیوسنسورها، مکانیزم تقویتکنندهها و ساختارهای حسگر زیستی مبتنی بر </span></span><span dir="LTR"><span style="color:#0d0d0d">SERS</span></span><span lang="AR-SA"><span style="color:#0d0d0d">، جهت تشخیص مولکولهای زیستی آشنا گردید.</span></span></span></span><br>
</span></span></span></div>
<span style="font-size:11pt"><span style="line-height:90%"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"><span style="color:red">Introduction:</span></span></span></span></i></b><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"> Surface-Enhanced Raman Scattering (SERS) is one of the most sensitive analytical tools currently known; in some cases, it is possible to obtain a high-quality SERS spectrum in which even a single molecule is involved. Therefore, SERS spectroscopy is considered an extremely promising option and an alternative to the routine analytical techniques applied in food, environmental, biochemical, and medical analyses.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:90%"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"><span style="color:red">Methods:</span></span></span></span></i></b><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"> The present review briefly discusses the definitive and recently developed applications of SERS spectroscopy for the biochemical characterization (especially medical and biological) of important compounds. The theoretical foundations of the SERS effect are also explained, and the future applications of SERS are discussed. The authors hope that this article will be useful for researchers who want to start their investigations in this amazing field of research.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:90%"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"><span style="color:red">Results:</span></span></span></span></i></b><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"> In this review article, the definitive and recently developed applications of SERS spectroscopy for the detection of biochemically (particularly medically and biologically) important species, from the simplest to the most complex ones, are briefly discussed. Moreover, the potentials of SERS to be used as an alternative to routine methods in diagnostic and clinical cases is demonstrated. In addition, it is described how SERS-based sensors work, and finally, future prospects are discussed.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:90%"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"><span style="color:red">Conclusion:</span></span></span></span></i></b><span style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"Times New Roman",serif"> By reading this article, the researcher will become familiar with the functions of diagnostics, direct and indirect fabrication methods for identifying biological analytes and chemicals, applications of biosensors, mechanisms of amplifiers, as well as structures of SERS-based biosensors applied to detect biomolecules.</span></span></span></span></span></span><br>
طیفسنجی رامان بهبودیافته سطحی (SERS), نانوحسگر زیستی, آنالیتهای بیولوژیکی, مواد شیمیایی, نانوذرات فلزی.
Surface-Enhanced Raman Spectroscopy (SERS), Biological Nanosensors, Biological Analytes, Chemicals, Metal Nanoparticles
33
47
http://icml.ir/browse.php?a_code=A-10-151-135&slc_lang=fa&sid=1
Vahid
Eskandari
وحید
اسکندری
1050031947532846005011
1050031947532846005011
No
Nanoscience and Nanotechnology Research Center, University of Kashan, Kashan, Iran
مرکز تحقیقات علوم و فناوری نانو، دانشگاه کاشان، کاشان، ایران
Hossein
Sahbafar
حسین
صهبافر
1050031947532846005012
1050031947532846005012
No
School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran
دانشکده مهندسی مکانیک، دانشکده فنی، دانشگاه تهران، تهران، ایران
Amin
Hadi
امین
هادی
amin.hadi@yums.ac.ir
1050031947532846005013
1050031947532846005013
Yes
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی یاسوج، یاسوج، ایران