en بررسی خواص فیزیکی و شیمیایی بافت کلاژنی قبل و بعد از تابش لیزر اگزایمر فرابنفش آرگون- فلوراید در خط 193 نانومتر عمومى General پژوهشي Research <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Tahoma;"><span style="font-size:14px;">&nbsp;<strong>مقدمه:</strong> تابش لیزر اگزایمر ArF با توجه به دوز تابش منجر به ایجاد دو فرآیند اتصال عرضی و تخریب نوری رشته&shy;‌های کلاژن در بافت خواهد شد. برای مشاهده و تخمین تغییرات پس از تابش لیزر از آزمون کششی استاتیک و طیف سنجی فروسرخ بهره گرفته شد.</span></span></span></p> <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Tahoma;"><span style="font-size:14px;"><strong>روش بررسی:</strong> نمونه‌&shy;های تهیه &shy;شده از کپسول کلیوی گوسفند، توسط لیزر اگزایمر با طول موج 193نانومتر تابش شده است. در آزمون کششی استاتیک، پارامترهایی چون مدول یانگ برای تخمین اثر تابش محاسبه شده‌&shy;اند . از آزمون مقدار P(01/0 P < ) و t دانشجویی برای بررسی اهمیت آماری داده&shy;‌های تجربی استفاده گردید. آزمون طیف&shy;‌سنجی FTIR نیز جهت مشاهده تغییرات ایجاد شده در ساختار شیمیایی و مولکولی بافت به &shy;کار رفته است .</span></span></span></p> <p style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Tahoma;"><span style="font-size:14px;"><strong>یافته‌&shy;ها و نتیجه‌&shy;گیری: </strong>کاهش مدول یانگ تا زمان پرتودهی 10 ثانیه نشان&shy;‌ دهنده این است که فاکتور جذب نور فرابنفش در باندهای پپتیدی منجر به انقطاع&shy;‌های جزئی در کلاژن و کاهش سفتی بافت می&shy;شود. درحالی&shy;که از زمان پرتودهی 10 تا 30 ثانیه پدیده جذب در اسیدهای آروماتیک غالب می&shy;‌باشد و سفتی بافت را افزایش می&shy;دهد. با افزایش دوز تابش، گسست پیوندها در بیشتر باندهای پپتیدی سفتی بافت را کاهش می&shy;دهد و شکسته&shy;‌شدن باندهای پپتیدی نیز منجر به کاهش فرکانس باند آمید II می&shy;گردد.</span></span></span></p> <span style="font-size:10pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="font-size:11.0pt"><span style="letter-spacing:.05pt">B</span></span></b><b><span 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style="letter-spacing:-.1pt">a</span>ce <span style="letter-spacing:.05pt">t</span>o <span style="letter-spacing:-.05pt">t</span>he <span style="letter-spacing:.05pt">l</span>o<span style="letter-spacing:-.05pt">w</span>er <span style="letter-spacing:.05pt">f</span><span style="letter-spacing:-.1pt">r</span>eque<span style="letter-spacing:-.1pt">n</span>c<span style="letter-spacing:-.1pt">y</span></span></span> کلاژن, لیزر اگزایمر آرگون فلوراید, مدول, طیف‌سنجی مادون قرمز Collagen, ArF Excimer laser (λ=193nm), Modulus, FTIR Spectroscopy 25 28 http://icml.ir/browse.php?a_code=A-10-6-104&slc_lang=en&sid=1 سوسن مختاری 1050031947532846004793 1050031947532846004793 No دانشکده فیزیک دانشگاه صنعتی امیر کبیر شقایق بقاپور 1050031947532846004794 1050031947532846004794 No دانشکده فیزیک دانشگاه صنعتی امیر کبیر پرویز پروین parvin@aut.ac.ir 1050031947532846004795 1050031947532846004795 Yes دانشکده فیزیک دانشگاه صنعتی امیر کبیر احمد امجدی 1050031947532846004796 1050031947532846004796 No دانشکده فیزیک دانشگاه صنعت شریف