Volume 19, Issue 3 (3-2023)
lmj 2023, 19(3): 34-48 |
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Pakroo M, Hassani S, Hashemi K S, Tabaie S M, Naderi M S. Investigation of proteins involved in the pathogenic process of coronavirus in different tissues. lmj 2023; 19 (3) :34-48
URL: http://icml.ir/article-1-578-en.html
URL: http://icml.ir/article-1-578-en.html
Department of Biophysics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran. ms.naderi@ian-tnb.ac.ir
Abstract: (920 Views)
Goals and Backgrounds:
It has been almost three years since the pandemic of coronavirus, which is scientifically known as SARS-COV-2 or Covid-19, started. At the beginning of this virus’s outbreak, it was assumed the lung tissue is the only target affected by this virus which may initially lead to respiratory and pulmonary symptoms and manifestations. However, nowadays it is clear that coronavirus has direct and indirect effects on different organs and tissues such as the brain, heart, kidneys, liver, lungs, skin, and hair.
Materials and Methods:
In this article, the function, and side-effects of SARS-COV-2 on different organs have been investigated. For this purpose, articles published in various databases such as PubMed, Science Direct, Google Scholar, Elsevier, and Scopus which were released over the last 3 years, have been discussed and analyzed.
Findings:
Reviewing previous studies shows that SARS-COV-2 is capable of producing various structural and non-structural proteins. With the help of these proteins and through their receptors in different tissues, various symptoms can be induced in the lungs, brain, heart, kidneys, liver, skin, and hair.
Conclusion:
With the recognition of the involved proteins as well as the pathogenic mechanisms of this virus in different tissues, the possibility of improving effective methods for treatment can be significantly enhanced.
It has been almost three years since the pandemic of coronavirus, which is scientifically known as SARS-COV-2 or Covid-19, started. At the beginning of this virus’s outbreak, it was assumed the lung tissue is the only target affected by this virus which may initially lead to respiratory and pulmonary symptoms and manifestations. However, nowadays it is clear that coronavirus has direct and indirect effects on different organs and tissues such as the brain, heart, kidneys, liver, lungs, skin, and hair.
Materials and Methods:
In this article, the function, and side-effects of SARS-COV-2 on different organs have been investigated. For this purpose, articles published in various databases such as PubMed, Science Direct, Google Scholar, Elsevier, and Scopus which were released over the last 3 years, have been discussed and analyzed.
Findings:
Reviewing previous studies shows that SARS-COV-2 is capable of producing various structural and non-structural proteins. With the help of these proteins and through their receptors in different tissues, various symptoms can be induced in the lungs, brain, heart, kidneys, liver, skin, and hair.
Conclusion:
With the recognition of the involved proteins as well as the pathogenic mechanisms of this virus in different tissues, the possibility of improving effective methods for treatment can be significantly enhanced.
Educational: Review |
Subject:
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Received: 2023/02/27 | Accepted: 2023/03/1 | Published: 2023/03/1
Received: 2023/02/27 | Accepted: 2023/03/1 | Published: 2023/03/1
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