Volume 19, Issue 3 (3-2023)
lmj 2023, 19(3): 1-10 |
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Beheshti Gozal Abad Sofla P, Aliannezhadi M, Masoudi A A. The effect of laser pulse radiation on treatment of intra-cranial space occupying lesion (ICSOL) by the photothermal method. lmj 2023; 19 (3) :1-10
URL: http://icml.ir/article-1-574-en.html
URL: http://icml.ir/article-1-574-en.html
Faculty of Physics, Semnan University, PO Box: 35195-363, Semnan, Iran
Abstract: (1021 Views)
Introduction: Although the percentage of the cases of intra-cranial space occupying lesion (ICSOL) increases with age and its percentage is about 1% compared to other cancers, unfortunately, this cancer has the lowest survival rate. Also, this cancer has caused the death of children more than any other disease, which shows the importance of precise investigation of the disease, its progress, and treatment methods.
Theory and method: Simulation of the treatment process is done by solving the three-dimensional Pennes bioheat transfer equation, with the accumulation of gold nanorods in the tumor, taking into account the temperature dependence of tissue and tumor characteristic coefficients, and taking into account the initial and boundary conditions with the finite element method (FEM). Then, the effects of using pulsed laser radiation with given laser on-off times are investigated.
Results: The results show that using the on-off process on laser radiation has a significant effect in controlling the temperature of the tumor in the vicinity of the symmetry axis in the upper border of the tumor which light enters the tumor through it. when the laser is turned off, the heat of these points can be transferred to other points through tissue and tumor heat conduction as well as blood perfusion. Therefore, the temperature of this area decreases during the turning-off the laser light, but the temperature changes in other areas of the tumor are less than in this area. Therefore, this method can be used as a powerful method to control the temperature of the tumor's central region and the success of the cancer treatment process.
Theory and method: Simulation of the treatment process is done by solving the three-dimensional Pennes bioheat transfer equation, with the accumulation of gold nanorods in the tumor, taking into account the temperature dependence of tissue and tumor characteristic coefficients, and taking into account the initial and boundary conditions with the finite element method (FEM). Then, the effects of using pulsed laser radiation with given laser on-off times are investigated.
Results: The results show that using the on-off process on laser radiation has a significant effect in controlling the temperature of the tumor in the vicinity of the symmetry axis in the upper border of the tumor which light enters the tumor through it. when the laser is turned off, the heat of these points can be transferred to other points through tissue and tumor heat conduction as well as blood perfusion. Therefore, the temperature of this area decreases during the turning-off the laser light, but the temperature changes in other areas of the tumor are less than in this area. Therefore, this method can be used as a powerful method to control the temperature of the tumor's central region and the success of the cancer treatment process.
Keywords: Intra-cranial space occupying lesion (ICSOL), Laser therapy, Metal nanostructures, Non-invasive treatment, Photothermal therapy (PTT)
Educational: Research |
Subject:
General
Received: 2023/02/27 | Accepted: 2023/03/1 | Published: 2023/03/1
Received: 2023/02/27 | Accepted: 2023/03/1 | Published: 2023/03/1
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