en عمومى General مروری Review <div style="text-align: justify;"><span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Effective management of infected wounds remains a clinical challenge, particularly in the context of increasing antimicrobial resistance and the emergence of multidrug-resistant (MDR) bacterial pathogens. Bacteriophage therapy has gained renewed interest as a potential alternative or adjunctive approach to conventional antimicrobial treatment. This review critically examines the role of phage therapy in infected wound management, with particular emphasis on bacterial targeting, biofilm disruption, wound-healing responses, and interactions with conventional antibiotics. Available experimental evidence suggests that phages can reduce bacterial burden and, in selected wound models, may be associated with improved re-epithelialization, granulation tissue formation, collagen organization, and vascularization. However, these effects appear to be closely related to effective infection control, and evidence for direct tissue-regenerative effects of phages remains limited. Phage therapy also presents important challenges, including narrow host range, emergence of phage resistance, variable biofilm activity, immune clearance, formulation and delivery constraints, and limited high-quality clinical evidence. Phage&ndash;antibiotic interactions may be synergistic, neutral, or antagonistic depending on the specific phage, antibiotic, bacterial strain, and treatment sequence. Therefore, current evidence supports phage therapy primarily as a targeted or adjunctive strategy for selected infected wounds, particularly those involving MDR or biofilm-associated pathogens, rather than as a universally superior replacement for antibiotics. Further well-designed clinical studies are needed to establish optimal phage selection, dosing, delivery strategies, and combination protocols and to determine their effects on clinically meaningful wound-healing outcomes.</span></span></span></span></span></span></span></div> Phage therapy, Wound Healing, Tissue Regeneration, Bacteriophages, Antibiotic Resistance, Dermal Proliferation 38 47 http://icml.ir/browse.php?a_code=A-10-480-6&slc_lang=en&sid=1 Seyedeh Sara Azadeh sara.azadehhh@gmail.com 1050031947532846005691 1050031947532846005691 Yes Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran Parniya Hemmati parniyahemmati9063@gmail.com 1050031947532846005692 0009-0003-6350-9584 No Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran